Fecal transplants reverse signs of aging in mice

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[EN VIDÉO] The gut microbiota, a precious ally for our health
There are different microbiota in the body: those of the skin, the mouth, the vagina… But the most important one is the gut microbiota. Scientists have long known about its potential, but the development of new techniques makes it possible to deepen the research to describe the nature of the interactions between host and microbiota, those of microorganisms between them, and their impact on health.

What if the bacteria that live in our gut could be a way to fight aging? The transplant by microbiota from a young mouse in an old mouse, age-related inflammation in the brainretina and intestine of rodents according to a new study published in Microbiome† It is not the first time that a grafting of microbiota allows to “rejuvenate” mice.

The microbiota reduces age-related inflammation

In this case, the scientists first killed the microbiota of the recipient mice before giving them fecal pellets containing the microbiota of a younger or older mouse. They also analyzed markers of inflammation in the brain, retina and gut of transplanted mice. When a young mouse is inoculated with a microbiota from an older rodent, it shows an age-specific inflammation. Conversely, an old mouse, inoculated with the microbiota of a young animal, sees these properties take up again.

The implications of this research are still unclear, but scientists believe that: modulations of the microbiota can prevent the inflammatory problems that occur with age. Research still needs to be done to determine the long-term benefits of these microbiota transplants on animal health and ultimately on human health.

Fecal transplant rejuvenates mice

Article byEleanor Sole published on August 15, 2021

In mice, the transplantation of a fecal microbiota from a young mouse to an old mouse appears to “rejuvenate” certain abilities of the mouse.

About two kilos micro organisms live in our digestive system, according to theinsert† By virusbacteria, mushrooms and parasites that affect our health, including our immune and neurological functions. A new study, published in Nature agingproposes that this microbiome could be a relevant therapeutic target to promote healthy aging.

A finding of transplants of microbiota fecal. The donors were mice, either 3 to 4 months old or 19 to 20 months old, while the recipients were systematically 19 to 20 months old. Only transplants from young mice had an effect. They have ” reverse aging differences on some aspects of immunity, the authors write, but they also have: impaired cognitive impairments associated with aging.

All in due time

Previous research […] have shown that the microbiome gut plays a key role in the aging and the aging process, recalls John Cryan, co-author of the study. This new research could be a game-changer, as we found that the microbiome could be used to reverse age-related brain deterioration. We also see evidence of improved learning ability and cognitive function.

These results may have important implications for the geriatrics or the prevention by symptoms of aging. But he is” still early warns John Cryan, to project himself into apps therapies: Much more work is needed to see how these findings translate to humans.

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