indication, for everyone in the fall?

The booster vaccine limits severe forms of Covid-19 disease by boosting the immune system. “There will be a proposal for an additional dose before the fall,” Professor Arnaud Fontanet estimated on May 4. For whom today? And for whom in the fall? Mandatory at 60?

[Mis à jour le 5 mai 2022 à 12h38] The vaccination Lake tar confronted with COVID-19 must continue even if the epidemic is receding In France. The fourth dose of vaccine (corresponding to a second booster dose) opens French of 60 and more and to all patients weakened immune system† †The Israeli data show us that for those over 60, the 4th dose divide by 4 our risk of hospitalization, so there is a real effect on severe forms and there is no more side effects than after the 3rd dose nor exhaustion of the immune response when you repeat the injections” indicates Professor Arnaud Fontanet on France 5 on May 4. †So there is no reason to refuse a fourth dose. Now there is a real fatigue. We can clearly see that this fourth dose is not necessary. It is true that with the decline of the BA.2 wave, people are telling themselves that in the end it may not be worth getting vaccinated nowadds the epidemiologist from the Institut Pasteur. “What is almost certain is that there is a strong proposal for an extra dose just before the start of autumn as we know there may be a recurrence of the epidemic, this will affect the population over 60 years of age. Will it go further, that is for the youngestwe do not know yet. It really depends on the epidemic situation. at this time“defended Professor Arnaud Fontanet. “We don’t rule out until the start of the school year“, in Sept, it is necessary to redo a 4th dose for the whole population, but we will see at that time according to the variants that will circulate Professor Bruno Mégarbane, head of the intensive care unit at the Lariboisière Hospital in Paris, told Franceinfo on April 24. “From April 25, under the 60-79 years, 3.3% received a second booster dose. By 80 years and olderwas the vaccination coverage of the second booster dose 13.2%Santé Publique France informs in its epidemiological update of 28 April. The appointment are open (possibility to accept them) doctolib and the vaccination can be performed in a vaccination center, pharmacy, practice or at home. Who should do 4 doses in France today? Is she obligated ? What are the indications and recommendations? How long after the third injection? † With which vaccine? Pfizer or Moderna?

4th dose of Covid vaccine: for whom?

Since April 7, the injection of a fourth dose of coronavirus vaccine is open to people 60 and older who are 6 months or more away from their first booster (or last covid infection). This second recall was already open to French people 80 years and older who received their booster dose more than 3 months ago and all patients weakened immune system (no longer just the “severely immunocompromised”). In line with COSV advice of November 2021, severely immunocompromised people involved in the 4th dose are:

  • solid organ transplant recipients,
  • recent bone marrow transplant recipients,
  • dialysis patients,
  • patients with autoimmune diseases undergoing aggressive immunosuppressive treatment, such as anti-CD20 or antimetabolites,
  • patients with certain types of lymphoma being treated with anti-CD20 or BTK inhibitors,
  • patients with chronic lymphocytic leukemia,
  • patients with rare forms of primary immunodeficiency,
  • myeloma under treatment

“From April 18, 2022, among the over-80s, the vaccination coverage of the second booster dose was 11.2% and 17.4% of those eligible on that date had received it. By 60-79 years, 2.7% received a second booster dose (28.8% of eligible in this age group)” reveals Public Health France on April 21.

What does the HAS recommend for the 4th dose?

The High Authority of Health (HAS) recommends a fourth dose of vaccine”people aged 65 and older with a very high risk of a severe form of the disease and/or polypathological and who so wish, as part of a medical decision shared with their healthcare team, taking into account their individual medical situation

Due to the still good efficacy of the vaccine (more than 70% in hospital admissions) 3 months after the first booster, the HAS recommends respecting an interval of at least 6 months with the first booster when using a second booster. The authority notes “that due to still limited data on the protection offered by an infection by Omicron, there is no there is no need to consider a second booster dose in people with recent SARS-CoV-2 infection with this variant, regardless of their age”

Is the 4th dose mandatory?

The fourth dose of coronavirus vaccine is not required but “open“, ie possibly for the people aged 60 and over who are 6 months or more from their first memory, persons aged at least 80 years and for all immunocompromised patients (starting 3 months after their first booster). So the 4th dose is not not required.

A 4th dose for everyone at the start of the school year in September?

According to several doctors, it is expected that a fourth dose of vaccine (second booster) will be offered to the entire French population (adult) at the beginning of the school year. This is in view of a possible resumption of the epidemic in the autumn and because the date of the last dose will be more than 6 months for most vaccinated people. “There will be a strong proposal for an extra dose just before the start of autumn as we know there may be a recurrence of the epidemic, this will affect the population over 60 years of age. Whether it will go further, that is, for the youngest, we do not yet know. It really depends epidemic situation at that time defended Professor Arnaud Fontanet on May 5. “We don’t rule out until the start of the school year“, in Sept, it is necessary to redo a 4th dose for the whole population, but we will see at that time according to the variants that will circulate Professor Bruno Mégarbane had also requisitioned on Franceinfo on April 24.

What do the vaccine manufacturing labs † Stéphane Bancel, CEO of modernahad assured at a press conference on Jan. 6 that a 4th dose of anti-Covid vaccine will most likely be needed:I still believe that we need boosters in the fall of 2022 and further.Albert Bourla, CEO of Pfizersaid Monday on BFM-TV January 17th: “Right now it is important to have three doses for a full vaccination, maybe a fourth dose a little later for the general population

How effective is the 4th dose?

The 4th dose divide by 4 our risk of hospitalization, so there is a real effect on severe forms and there is no more side effects than after the 3rd dose nor exhaustion of the immune response when you repeat the injections” Professor Arnaud Fontanet indicates on 5 May. †It is known that a second booster vaccination [ou quatrième dose] reduces the risk of hospitalization, CPR and death by 80%“Olivier Véran announced this on April 7 on RTL.”After a booster injection of the Pfizer vaccine, vaccine efficacy against hospitalizations was 90% and decreased to approximately 85% after 5 to 9 weeks and then to 75% after 10 to 14 weeks† After a booster with the Moderna vaccine, the booster effectiveness against hospitalization was: 90-95% up to 9 weeks after vaccination has indicated in its advice of March 17, 2022.

How long does it take to take your 4th dose?

► from 60 to 79 years: from 6 months or more from the first booster or from 6 months after the last infection.

For people who have already had the Covid after their first memory:

  • If the infection occurred more than 3 months after the first booster, second reminder is not necessary.
  • If the infection occurred less than 3 months after the first booster, a second booster is needed. You must then wait at least 6 months after the infection before you receive your second booster.

► From 80 years and for immunocompromised: the fourth dose of the vaccine is for those who have since received their booster dose more than 3 months.

► In severely immunocompromised people the fourth dose of vaccine is part of their full primary vaccination schedule. They can then call back on medical advice. she is performed one month after the 3rd dose.

Moderna or Pfizer: Which Vaccine for the 4th Dose?

The booster dose for eligible people is ready only with an mRNA vaccine, either Pfizer (30 µg dose) or Moderna (50 µg dose), regardless of the previously used vaccine(s) according to the COSV. The Pfizer vaccine is the only one recommended for people under the age of 30. †A full dose of Pfizer-BioNTech vaccine or a half dose of Moderna vaccine be used for this second booster shotrecommends the DGS.

What is the result of the fourth dose in Israel?

Israel began on January 3, 2022 at inject a fourth dose”for people of 60 and more, medical personnel and employees of health and social protection institutions, in addition to immunocompromised people who have been involved since Dec. 31, according to the country’s health ministry. †The Israeli data show us that for those over 60, the 4th dose divide by 4 our risk of hospitalization, so there is a real effect on severe forms and there is no more side effects than after the 3rd dose nor exhaustion of the immune response when you repeat the injections” indicates Professor Arnaud Fontanet on France 5 on May 4.

sources:

Vaccine Strategy Guidance Council Recommendations for the Protection of Severely Immunocompromised People from Covid-19 (Vaccination and Primary Prophylaxis) – November 19, 2021

Launch of the Covid-19 Vaccine Booster Campaign for Priority Populations – DGS – August 27, 2021

Vaccine Strategy Advisory Council Advice of 19 August 2021 – Minimum time between primary vaccination and booster vaccination

Leave a Comment